SWCho
Seung Woo Cho, PhD

Entire publications of PI are available through the following links.

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Publications

Assistant professor (2019~2025)

  1. Kim, D., S. Park, Y. R. Kim, H. Yoon, B. S. Cho, I. Baek, J. H. Kang, T. E. Park, M. R. Corces, H. J. Kim, Y. J. Kim, and S. W. Cho. Analysis of chromatin accessibility associated with azacitidine response in higher-risk myelodysplastic neoplasms. iScience (In press)
  2. Cheng, H., E. Jeong, and S. W. Cho. Applications of multiplexed CRISPR/Cas for genome engineering. Experimental and Molecular Medicine (2025)
  3. Lee, S., K. Kim, H. J. Jeong, S. Choi, H. Cheng, D. Kim, S. Heo, J. Mun, M. Kim, E. Lee, Y. J. Choi, S. G. Lee, E. A. Lee, Y. Jang, K. Lim, H. S. Kim, E. Jeong, S. J. Myung, D. B. Jung, C. S. Yu, I. H. Song, M. R. Corces, J. H. Kang, K. Myung, T. Kwon, T. E. Park, J. Joo, and S. W. Cho. Combining Multiplexed Crispr/Cas9-Nickase and Parp Inhibitors Efficiently and Precisely Targets Cancer Cells. Cancer Res (2025).
  4. Park, S. J., I. Park, S. Kim, M. K. Kim, S. Kim, H. Jeong, D. Kim, S. W. Cho, T. E. Park, A. Ni, H. Lim, J. Joo, J. H. Lee, and J. H. Kang. Extracorporeal Blood Treatment Using Functional Magnetic Nanoclusters Mitigates Organ Dysfunction of Sepsis in Swine. Small Methods 8 (2024): e2301428.
  5. Yoon, H., J. H. Kang, S. W. Cho, C. G. Park, D. W. Kim, and T. E. Park. Brain-Decellularized Ecm-Based 3d Myeloid Sarcoma Platform: Mimicking Adaptive Phenotypic Alterations in the Brain. Adv Healthc Mater 13 (2024): e2304371.
  6. Yoon, H., J. Sabate Del Rio, S. W. Cho, and T. E. Park. Recent Advances in Micro- Physiological Systems for Investigating Tumor Metastasis and Organotropism. Lab Chip 24 (2024):
  7. Jeong, H., H. E. Moon, S. Yun, S. W. Cho, H. R. Park, S. H. Park, K. Myung, T. Kwon, and S. H. Paek. Enrichment of Deleterious Mutated Genes Involved in Ciliary Function and Histone Modification in Brain Cancer Patient-Derived Xenograft Models. Biomedicines 11 (2023).
  8. Oh, J. M., Y. Kang, J. Park, Y. Sung, D. Kim, Y. Seo, E. A. Lee, J. S. Ra, E. Amarsanaa, Y. U. Park, S. Y. Lee, J. M. Hwang, H. Kim, O. Scharer, S. W. Cho, C. Lee, K. I. Takata, J. Y. Lee, and K. Myung. Msh2-Msh3 Promotes DNA End Resection During Homologous Recombination and Blocks Polymerase Theta-Mediated End-Joining through Interaction with Smarcad1 and Exo1. Nucleic Acids Res 51 (2023): 5584-602.
  9. Park, J. I., S. W. Cho, J. H. Kang, and T. E. Park. Intestinal Peyer’s Patches: Structure, Function, and in Vitro Modeling. Tissue Eng Regen Med 20 (2023): 341-53.
  10. Choi, J. W., M. Seo, K. Kim, A. R. Kim, H. Lee, H. S. Kim, C. G. Park, S. W. Cho, J. H. Kang, J. Joo, and T. E. Park. Aptamer Nanoconstructs Crossing Human Blood-Brain Barrier Discovered Via Microphysiological System-Based Selex Technology. ACS Nano 17 (2023): 8153-66.
  11. Kwon, T., J. S. Ra, S. Lee, I. J. Baek, K. W. Khim, E. A. Lee, E. K. Song, D. Otarbayev, W. Jung, Y. H. Park, M. Wie, J. Bae, H. Cheng, J. H. Park, N. Kim, Y. Seo, S. Yun, H. E. Kim, H. E. Moon, S. H. Paek, T. J. Park, Y. U. Park, H. Rhee, J. H. Choi, S. W. Cho, and K. Myung.

    Precision Targeting Tumor Cells Using Cancer-Specific Indel Mutations with Crispr-Cas9. Proc Natl Acad Sci U S A 119 (2022).

  12. Shin, H. M., G. Kim, S. Kim, J. H. Sim, J. Choi, M. Kim, M. Kwon, S. K. Ye, D. S. Lee, S. W. Cho, S. T. Kim, J. Lee, and H. R. Kim. Chromatin Accessibility of Circulating Cd8(+) T Cells Predicts Treatment Response to Pd-1 Blockade in Patients with Gastric Cancer. Nat Commun 12(2021): 975.
  13. Lee, H., H. Y. Chang, S. W. Cho, and H. P. Ji. Crisprpic: Fast and Precise Analysis for Crispr- Induced Mutations Via Prefixed Index Counting. NAR Genom Bioinform 2 (2020): lqaa012.

Postdoctoral researcher (2014~2018)

  1. Kebschull, J. M., E. B. Richman, N. Ringach, D. Friedmann, E. Albarran, S. S. Kolluru, R. C. Jones, W. E. Allen, Y. Wang, S. W. Cho, H. Zhou, J. B. Ding, H. Y. Chang, K. Deisseroth, S. R. Quake, and L. Luo. Cerebellar Nuclei Evolved by Repeatedly Duplicating a Conserved Cell- Type Set. Science (2020).
  2. Carter, A. C., J. Xu, M. Y. Nakamoto, Y. Wei, B. J. Zarnegar, Q. Shi, J. P. Broughton, R. C. Ransom, A. Salhotra, S. D. Nagaraja, R. Li, D. R. Dou, K. E. Yost, S. W. Cho, A. Mistry, M. T.
    Longaker, P. A. Khavari, R. T. Batey, D. S. Wuttke, and H. Y. Chang. Spen Links Rna-Mediated Endogenous Retrovirus Silencing and X Chromosome Inactivation. Elife (2020).
  3. Corces, M. R., J. M. Granja, S. Shams, B. H. Louie, J. A. Seoane, W. Zhou, T. C. Silva, C. Groeneveld, C. K. Wong, S. W. Cho, A. T. Satpathy, M. R. Mumbach, K. A. Hoadley, A. G. Robertson, N. C. Sheffield, I. Felau, M. A. A. Castro, B. P. Berman, L. M. Staudt, J. C. Zenklusen, P. W. Laird, C. Curtis, Network Cancer Genome Atlas Analysis, W. J. Greenleaf, and H. Y. Chang. The Chromatin Accessibility Landscape of Primary Human Cancers. Science 362 (2018).
  4. Cho, S. W., J. Xu, R. Sun, M. R. Mumbach, A. C. Carter, Y. G. Chen, K. E. Yost, J. Kim, J. He,
    S. A. Nevins, S. F. Chin, C. Caldas, S. J. Liu, M. A. Horlbeck, D. A. Lim, J. S. Weissman, C. Curtis, and H. Y. Chang. Promoter of Lncrna Gene Pvt1 Is a Tumor-Suppressor DNA Boundary Element. Cell 173 (2018): 1398-412 e22.
  5. Mumbach, M. R., A. T. Satpathy, E. A. Boyle, C. Dai, B. G. Gowen, S. W. Cho, M. L. Nguyen, A.
    J. Rubin, J. M. Granja, K. R. Kazane, Y. Wei, T. Nguyen, P. G. Greenside, M. R. Corces, J. Tycko, D. R. Simeonov, N. Suliman, R. Li, J. Xu, R. A. Flynn, A. Kundaje, P. A. Khavari, A. Marson, J. E. Corn, T. Quertermous, W. J. Greenleaf, and H. Y. Chang. Enhancer Connectome in Primary Human Cells Identifies Target Genes of Disease-Associated DNA Elements. Nat Genet 49 (2017): 1602-12.
  6. Corces, M. R., A. E. Trevino, E. G. Hamilton, P. G. Greenside, N. A. Sinnott-Armstrong, S. Vesuna, A. T. Satpathy, A. J. Rubin, K. S. Montine, B. Wu, A. Kathiria, S. W. Cho, M. R. Mumbach, A. C. Carter, M. Kasowski, L. A. Orloff, V. I. Risca, A. Kundaje, P. A. Khavari, T. J. Montine, W. J. Greenleaf, and H. Y. Chang. An Improved Atac-Seq Protocol Reduces Background and Enables Interrogation of Frozen Tissues. Nat Methods 14 (2017): 959-62.
  7. Liu, S. J., M. A. Horlbeck, S. W. Cho, H. S. Birk, M. Malatesta, D. He, F. J. Attenello, J. E. Villalta, M. Y. Cho, Y. Chen, M. A. Mandegar, M. P. Olvera, L. A. Gilbert, B. R. Conklin, H. Y. Chang, J. S. Weissman, and D. A. Lim. Crispri-Based Genome-Scale Identification of Functional Long Noncoding Rna Loci in Human Cells. Science 355 (2017).
  8. Chen, X., Y. Shen, W. Draper, J. D. Buenrostro, U. Litzenburger, S. W. Cho, A. T. Satpathy, A.
    C. Carter, R. P. Ghosh, A. East-Seletsky, J. A. Doudna, W. J. Greenleaf, J. T. Liphardt, and H.
    Y. Chang. Atac-See Reveals the Accessible Genome by Transposase-Mediated Imaging and Sequencing. Nat Methods 13 (2016): 1013-20.
  9. Cho, S. W. and H. Y. Chang. Genomics: Crispr Engineering Turns on Genes. Nature 517 (2015): 560-2.

Ph.D. course (2007~2014)

  1. Woo, J. W., J. Kim, S. I. Kwon, C. Corvalan, S. W. Cho, H. Kim, S. G. Kim, S. T. Kim, S. Choe, and J. S. Kim. DNA-Free Genome Editing in Plants with Preassembled Crispr-Cas9 Ribonucleoproteins. Nat Biotechnol 33 (2015): 1162-4.
  2. Hyun, Y., J. Kim, S. W. Cho, Y. Choi, J. S. Kim, and G. Coupland. Site-Directed Mutagenesis in Arabidopsis Thaliana Using Dividing Tissue-Targeted Rgen of the Crispr/Cas System to Generate Heritable Null Alleles. Planta 241 (2015): 271-84.
  3. Kim, S., D. Kim, S. W. Cho, J. Kim, and J. S. Kim. Highly Efficient Rna-Guided Genome Editing in Human Cells Via Delivery of Purified Cas9 Ribonucleoproteins. Genome Res 24 (2014): 1012-9.
  4. Ramakrishna, S., S. W. Cho, S. Kim, M. Song, R. Gopalappa, J. S. Kim, and H. Kim. Surrogate Reporter-Based Enrichment of Cells Containing Rna-Guided Cas9 Nuclease-Induced Mutations. Nat Commun 5 (2014): 3378.
  5. Cho, S. W., S. Kim, Y. Kim, J. Kweon, H. S. Kim, S. Bae, and J. S. Kim. Analysis of Off-Target Effects of Crispr/Cas-Derived Rna-Guided Endonucleases and Nickases. Genome Res 24 (2014): 132-41.
  6. Cho, S. W., J. Lee, D. Carroll, J. S. Kim, and J. Lee. Heritable Gene Knockout in Caenorhabditis Elegans by Direct Injection of Cas9-Sgrna Ribonucleoproteins. Genetics 195, no. 3 (2013): 1177-80.
  7. Cho, S. W., S. Kim, J. M. Kim, and J. S. Kim. Targeted Genome Engineering in Human Cells with the Cas9 Rna-Guided Endonuclease. Nat Biotechnol 31 (2013):

PATENTS

  1. SW Cho, S Lee, KJ Myung, T Kwon (2024) Cell death method using CRISPR/Cas system having single-strand break activity and PARP inhibitor. PCT/KR2024/012084
  2. KJ Myung, TJ Kwon, IJ Baek, JS Ra, YH Park, WJ Chung, OV Daniyar, SW Cho (2021) Composition For Inducing Death of Cells Having Genomic Sequence Variations And Method For Inducing Death of Cells Having Genomic Sequence Variations Using the Same. KR20210116324A (KR/PTC)
  3. JS Kim, SW Cho, and S Kim (2016). Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof. 1016562360000 (KR/PTC)